A landmark Nature study from Harvard found that lithium was the only metal significantly depleted in the brains of people with mild cognitive impairment. In mice, cutting lithium by about half triggered amyloid buildup, tau pathology, inflammation, and memory loss, while low-dose lithium orotate prevented it. The compound appears to evade the amyloid plaques that trap other lithium salts. But the supplement results are mouse-only, with no human trial yet, and lithium carries real kidney, thyroid, and interaction risks. Here is what the study shows, what it doesn't, and what to watch next.
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